Alison C Donnelly Selected Research

Novobiocin (Streptonivicin)

12/2011	A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells.
6/2011	Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.
1/2010	Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
11/2008	The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.

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Alison C Donnelly Research Topics

Disease

6	Neoplasms (Cancer) 10/2012 - 11/2008
1	Melanoma (Melanoma, Malignant) 12/2011
1	Prostatic Neoplasms (Prostate Cancer) 01/2010
1	Breast Neoplasms (Breast Cancer) 11/2008

Drug/Important Bio-Agent (IBA)

4	Novobiocin (Streptonivicin)FDA Link 12/2011 - 11/2008
3	Proteins (Proteins, Gene)FDA Link 12/2011 - 11/2008
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2011 - 12/2009
2	tanespimycin (17AAG)IBA 12/2011 - 01/2010
1	Oncogene Proteins (Oncogene Protein)IBA 10/2012
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2012
1	Pharmaceutical PreparationsIBA 10/2012
1	Small Interfering RNA (siRNA)IBA 10/2012
1	Cytostatic AgentsIBA 10/2012
1	Cytochromes c (Cytochrome c)IBA 12/2011
1	KU135IBA 12/2011
1	Annexin A5IBA 12/2011
1	Caspase 3 (Caspase-3)IBA 12/2011
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2011
1	Biological ProductsIBA 06/2011
1	geldanamycinIBA 02/2010
1	F 4 (F-4)IBA 01/2010
1	Topoisomerase II InhibitorsIBA 11/2008
1	NucleotidesIBA 11/2008

Therapy/Procedure

1	Therapeutics 12/2011